This systematic review and network meta-analysis investigated whether different vitamins, nutrients and dietary supplements can affect recovery and inflammation in adults with COVID-19. The researchers compiled 45 randomized controlled trials from 18 countries with a total of 3,793 patients.
The results show that some supplements can affect individual markers of inflammation. Vitamin C together with standard treatment reduced the inflammatory marker IL-6, while nanocurcumin increased the number of lymphocytes. Pomegranate juice also affected the ratio between neutrophils and lymphocytes, but the results were more uncertain and partly contradictory.
Most importantly, however, the researchers did not see any definite improvement in several clinically important outcomes. The dietary supplements did not reduce mortality and had no clear effect on, among other things, CRP, white blood cell count, neutrophils, fever, headache, cough or shortness of breath compared with standard treatment.
The researchers also emphasize that the results must be interpreted with caution. For several comparisons, the number of patients was small, a large part of the results were based on indirect comparisons and the evidence was often assessed as low or very low. Of the 45 included studies, 13 had a high risk of bias and a further eight had some methodological issues. The researchers themselves point out that the very large estimated reduction in IL-6 with vitamin C is likely unstable and should not be considered a reliable measure of treatment effect. The conclusion is therefore not that vitamins or dietary supplements can replace standard Covid treatment. Rather, the study shows that certain supplements can possibly affect specific laboratory values and therefore may be interesting as complementary treatment in certain situations. However, there is not yet strong enough evidence to say that they improve the most important clinical outcomes, and larger and better randomized studies are needed.
Text translated from Swedish, originally written by Patrik Andersson and published in Facebook group SARS-CoV-2 Omvärldsbevakning
Category: Treatment
A large randomized trial investigated whether vitamin D3 supplementation can improve the course of COVID-19. The study included 1,747 people who had recently been diagnosed with COVID-19 and their household contacts. Participants were given either high doses of vitamin D3 for one month or a placebo.
The results showed that vitamin D did not reduce how often patients needed healthcare, such as hospital visits, emergency room visits or doctor visits. It also did not reduce the severity of symptoms, and it did not affect the risk of family members in the same household becoming infected.
However, the researchers saw a slight trend towards fewer persistent symptoms after two months in those who received vitamin D. Around 21% in the vitamin D group reported long-term symptoms compared to 25% in the placebo group. However, the difference was small and not statistically significant.
The researchers therefore believe that vitamin D is unlikely to reduce acute illness or the need for care in COVID-19, but that it may be worth studying further whether vitamin D can affect the risk of long-term symptoms after infection. No safety concerns with the treatment were reported.
Credit: Patrik Andersson
When a cell gets infected by SARS-Cov-2 it causes chaos in the cells RNA functions in many different ways and ultimately creates havoc in how the cell functions.
https://www.gu.se/en/news/coronavirus-causes-chaos-in-infected-cells-rna
Hre is a easier to understand article about the study on Pegylated Interferon Lambda that was published here earlier. And yep. 50% reduction in risk for severe covid and death.
Results for early treatment with pegylated interferon lambda shows improved outcome for majority of patients.
Covid affects the brain. For almost everyone that gets infected. Have you lost smell and/or taste at some point, you can be sure it has altered your brain.
Some research indicates that micro-clots have a big part in forming Long Covid.
Categories
IVERMECTIN DEBUNKED
It doesn’t work on Covid-19. Don’t believe the hype.
https://www.nejm.org/doi/full/10.1056/NEJMoa2201662?query=featured_home&fbclid=IwAR2_BgbtXjDYQbqo4o974b2mtUGLJUhqjKHDONbhXFDH-aBvG7Sv0uVLwr4