A new large study of over 1,150 people hospitalized for COVID-19 shows that an infection with SARS-CoV-2 can activate viruses that had previously been dormant in the body. Almost half of the patients experienced such a virus reactivation, even though they had no known compromised immune system.
The researchers found that Epstein–Barr virus (EBV), cytomegalovirus (CMV) and so-called anelloviruses, among others, became active during different stages of the disease. People in whom these viruses were reactivated more often had a more severe COVID-19 in the first few weeks.
The study also investigated whether virus reactivation could be linked to long-term COVID. Unlike some previous studies, no clear connection was found between Epstein–Barr virus and long-term symptoms. However, a connection was seen between activation of anelloviruses and persistent symptoms such as fatigue and reduced physical strength. However, the researchers emphasize that the study cannot prove that the viruses cause the symptoms – only that they occur together.
The results also suggest that activated anelloviruses can affect the immune system and contribute to impaired immune regulation, but this needs to be confirmed in more studies.
The researchers point out that the participants in the study were unvaccinated and were infected with the early variants of the coronavirus before mid-2021. Therefore, it cannot be said that the results apply in the same way to people who have been vaccinated or infected with later virus variants.
The next step will be to investigate whether drugs that can prevent dormant viruses from activating can also reduce the risk of or alleviate long-term symptoms after covid-19. This could provide a better understanding of why some people develop long-term covid while others recover completely. (Translated from Swedish text written by Patrik Andersson in FB group SARS-CoV-2 Omvärldsbevakning )
Category: Hospitalisation
A large randomized trial investigated whether vitamin D3 supplementation can improve the course of COVID-19. The study included 1,747 people who had recently been diagnosed with COVID-19 and their household contacts. Participants were given either high doses of vitamin D3 for one month or a placebo.
The results showed that vitamin D did not reduce how often patients needed healthcare, such as hospital visits, emergency room visits or doctor visits. It also did not reduce the severity of symptoms, and it did not affect the risk of family members in the same household becoming infected.
However, the researchers saw a slight trend towards fewer persistent symptoms after two months in those who received vitamin D. Around 21% in the vitamin D group reported long-term symptoms compared to 25% in the placebo group. However, the difference was small and not statistically significant.
The researchers therefore believe that vitamin D is unlikely to reduce acute illness or the need for care in COVID-19, but that it may be worth studying further whether vitamin D can affect the risk of long-term symptoms after infection. No safety concerns with the treatment were reported.
Credit: Patrik Andersson
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What SARS-CoV-2 Does to the Body (2nd Edition, July 2023)
An extensive compilation of links to studies and statistics on what SARS-Cov-2 does to your body, brain etc. And it is way worse than most people know.
https://www.panaccindex.info/p/what-sars-cov-2-does-to-the-body
What determines how ill the acute phase of Covid-19 will make you regarding to pneumonia? It seems to be your DNA.
Hre is a easier to understand article about the study on Pegylated Interferon Lambda that was published here earlier. And yep. 50% reduction in risk for severe covid and death.
Why heart lesions in children happens as a result of Covid-19 infection.
Declining levels of T-cells, infection after infection, declining health, weird skin cancer, pneumonia that won’t resolve even with tons of antibiotics; does it sound familiar? We might be looking at this again, 40 years after the AIDS-epidemic hit USA and Western Europe…
After a Covid infection the risk of many heart and vascular diseases multiplies…
Research shows your genes might affect how your body responds to a SARS-Cov-2 infection.
There are coming reports on Covid’s effects on the immune system, and neither of them are sunny. This study from the Linköping University in Sweden shows that severe cases has long lasting effects on T-cells and other parts of the immune system similar to chronic HIV-infections. Yet another reason to not get infected.
https://liu.se/en/news-item/svar-covid-19-ger-langvariga-negativa-effekter-pa-immunforsvaret
https://www.frontiersin.org/articles/10.3389/fimmu.2022.931039/full