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Is the Hygiene Hypothesis True?

Nope. Been debunked for both infections and allergens.

https://publichealth.jhu.edu/2022/is-the-hygiene-hypothesis-true

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Adults Antibodies CD14+ monocytes - White blood cells Children Immune system T-cells Th17 helper cells

Time to abandon the hygiene hypothesis: new perspectives on allergic disease, the human microbiome, infectious disease prevention and the role of targeted hygiene

The Hygiene Hypothesis has been under debate for quite a few years, or rather decades, and it is time to scrap it; the immune system doesn’t work like that. We don’t need repeated infections to stay health and have a functioning immune defense.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966430/